(Biology) To shed or cast off dead skin, scales, or an outer layer
"Snakes slough off their skin several times a year as they grow."
To shed dead skin or an outer layer, or figuratively to discard something unwanted such as a habit or attitude
To peel off dead skin, or to get rid of something you no longer want or need
2 meanings, ordered from most common to least. Color-coded by CEFR level.
(Biology) To shed or cast off dead skin, scales, or an outer layer
"Snakes slough off their skin several times a year as they grow."
(Figurative) To get rid of something unwanted, such as a habit, attitude, or old identity
"She moved to a new city hoping to slough off her reputation and start fresh."
To shed dead outer skin, as a snake does
To peel off dead skin, or to get rid of something you no longer want or need
The literal biological sense (skin, scales) is technical. The figurative sense (slough off old habits, a past identity) appears in literary and formal writing. The word 'slough' rhymes with 'tough', not 'though'.
Natural word combinations native speakers use most often.
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