To put in an enormous, exhausting amount of effort.
"She knocked herself out organising the fundraiser, and it showed — the event was flawless."
To make an extreme effort, or (sarcastically) to give someone reluctant permission to do what they want.
To try very hard, or (in a joking way) to tell someone to go ahead and do whatever they want.
2 meanings, ordered from most common to least. Color-coded by CEFR level.
To put in an enormous, exhausting amount of effort.
"She knocked herself out organising the fundraiser, and it showed — the event was flawless."
Used as a sarcastic or ironic expression meaning 'go ahead' or 'feel free,' often implying the speaker doubts the person will succeed or doesn't care.
"'Can I try to fix it myself?' 'Knock yourself out — I've already given up on it.'"
To hit yourself hard enough to lose consciousness.
To try very hard, or (in a joking way) to tell someone to go ahead and do whatever they want.
Two very different senses depending on tone. In the sincere sense, it means to exhaust yourself with effort ('she knocked herself out planning the party'). In the sarcastic/ironic sense, 'knock yourself out' means 'be my guest' or 'go ahead' — often implying the speaker doesn't care or is amused. Tone of voice is crucial.
Natural word combinations native speakers use most often.
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